Michael J. Steinbaugh, PhD
Scientist II, Constellation Pharmaceuticals
215 First St., Cambridge, MA 02142
Research scientist focused on genomics, with current emphasis on epigenetic regulation of transcription. Trained in genetics, bioinformatics, molecular biology, microbiology, and immunology. Adept at single-cell genomics and next-generation sequencing data analysis. Active participant in open-source software development.
Bioinformatics software and tutorials are available at steinbaugh.com.
- PhD, Cellular and Molecular Biology, University of Michigan (2012)
- BS, Microbiology, Immunology and Molecular Genetics; Spanish Minor, UCLA (2005)
- Wu Z, Isik M, Moroz N, Steinbaugh MJ, Zhang P, Blackwell TK.
Dietary restriction extends lifespan through metabolic regulation of innate immunity.
Cell Metabolism [Epub ahead of print].
- Klim JR, Williams LA, Limone F, Guerra San Juan I, Davis-Dusenbery BN, Mordes DA, Burberry A, Steinbaugh MJ, Gamage KK, Kirchner R, Moccia R, Cassel SH, Chen K, Wainger BJ, Woolf CJ, Eggan K.
ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair.
Nature Neuroscience 22:167-179.
- Steinbaugh MJ, Pantano L, Kirchner RD, Barrera V, Chapman BA, Piper ME, Mistry M, Khetani RS, Rutherford KD, Hoffman O, Hutchinson JN, Ho Sui SJ.
bcbioRNASeq: R package for bcbio RNA-seq analysis.
- Blackwell TK, Steinbaugh MJ, Hourihan JM, Ewald CY, Isik M.
SKN‑1/Nrf, stress responses, and aging in Caenorhabditis elegans.
Free Radical Biology and Medicine 88:290-301. Review.
- Steinbaugh MJ, Narasimhan SD, Robida-Stubbs S, Moronetti Mazzeo LE,
Dreyfuss JM, Hourihan JM, Raghavan P, Operaña TN, Esmaillie R, Blackwell TK.
Lipid-mediated regulation of SKN‑1/Nrf in response to germ cell absence.
- Yoon JC, Ling AJ, Isik M, Lee DY, Steinbaugh MJ, Sack LM, Boduch AN,
Blackwell TK, Sinclair DA, Elledge SJ.
GLTSCR2/PICT1 links mitochondrial stress and Myc signaling.
Proceedings of the National Academy of Sciences of the United States of America 111:3781-6.
- Steinbaugh MJ, Sun LY, Bartke A, Miller RA.
Activation of genes involved in xenobiotic metabolism is a shared signature of
mouse models with extended lifespan.
American Journal of Physiology-Endocrinology and Metabolism 303:E488-95.
- Sun LY, Steinbaugh MJ, Masternak MM, Bartke A, Miller RA.
Fibroblasts from long-lived Snell and GHRKO mutant mice show diminished ERK
phosphorylation but exaggerated induction of immediate early genes.
Free Radical Biology and Medicine 47:1753-61.