Michael J. Steinbaugh, Ph.D.

Research Fellow at the Joslin Diabetes Center

Curriculum Vitae

Michael J. Steinbaugh, Ph.D.
Research Fellow
Harvard Medical School
Joslin Diabetes Center
T. Keith Blackwell Lab
Islet Cell and Regenerative Biology
1 Joslin Place, Boston, MA 02215
mike@steinbaugh.com

Education

09/05-04/12

Ph.D., Cellular and Molecular Biology
University of Michigan Medical School

09/01-06/05

B.S., Microbiology, Immunology and Molecular Genetics
Minor in Spanish Language
University of California, Los Angeles

Additional

09/09-12/09

Financing Research Commercialization
Stephen M. Ross School of Business, University of Michigan

09/08

Molecular Biology of Aging
Marine Biological Laboratory, Woods Hole, MA

Research Training

09/12-Pres.

Research Fellow
Islet Cell and Regenerative Biology, Joslin Diabetes Center;
Department of Genetics, Harvard Medical School
Mentor: T. Keith Blackwell, M.D., Ph.D., Professor

05/12-08/12

Research Fellow
Department of Pathology, University of Michigan Medical School
Mentor: Richard A. Miller, M.D., Ph.D., Professor

09/05-04/12

Ph.D. Student
Cellular and Molecular Biology, University of Michigan Medical School
Mentor: Richard A. Miller, M.D., Ph.D., Professor
Thesis: "Xenobiotic-metabolizing enzymes elevated in multiple mouse models of slow aging"

07/04-09/04

Research Intern
The Buck Institute for Research on Aging
Mentor: Lisa M. Ellerby, Ph.D., Associate Professor

09/03-06/05

Research Assistant
Department of Microbiology, Immunology and Molecular Genetics, UCLA
Mentor: Kenneth A. Bradley, Ph.D., Associate Professor
Thesis: "Identification of PA-competitive peptides via phage display"

Publications

02/20/2014

John C. Yoon, Alvin J. Y. Ling, Meltem Isik, Dong-Young Donna Lee, Michael J. Steinbaugh, Laura M. Sack, Abigail N. Boduch, T. Keith Blackwell, David A. Sinclair, Stephen J. Elledge. "GLTSCR2/PICT1 links mitochondrial stress and Myc signaling." Proc Natl Acad Sci U S A Epub ahead of print. doi:10.1073/pnas.1400705111; pmid:24556985

06/12/2012

Michael J. Steinbaugh, Liou Y. Sun, Andrzej Bartke, and Richard A. Miller. "Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan." Am J Physiol Endocrinol Metab 303:E488-95. doi:10.1152/ajpendo.00110.2012; pmid:22693205

09/26/2009

Liou Y. Sun, Michael J. Steinbaugh, Michal M. Masternak, Andrzej Bartke, and Richard A. Miller. "Fibroblasts from long-lived Snell and GHRKO mutant mice show diminished ERK phosphorylation but exaggerated induction of immediate early genes." Free Radic Biol Med 47:1753-61. doi:10.1016/j.freeradbiomed.2009.09.021; pmid:19786089

Presentations

Talks

03/26/2014

Michael J. Steinbaugh*, Sri Devi Narasimhan*, Stacey Robida-Stubbs*, Prashant Raghavan, Lorenza Moronetti, John M. Hourihan, Theresa Operana, and T. Keith Blackwell. "Novel lipid metabolism and proteasome regulatory functions of SKN-1/Nrf in the germ cell longevity pathway." Boston Area Worm Meeting, MIT

06/27/2013

Michael J. Steinbaugh*, Sri Devi Narasimhan*, Stacey Robida-Stubbs*, Prashant Raghavan, Lorenza Moronetti, Theresa Operana, and T. Keith Blackwell. "Regulation of SKN-1/Nrf by the germline longevity pathway." 19th International C. elegans Meeting, UCLA

03/19/2013

Michael J. Steinbaugh*, Sri Devi Narasimhan*, Stacey Robida-Stubbs*, Prashant Raghavan, Theresa Operana, and T. Keith Blackwell. "SKN-1 is a novel regulator of the germline longevity pathway." Harvard Stem Cell Institute Salon on Aging

04/20/2012

Michael J. Steinbaugh and Richard A. Miller. "Xenobiotic-metabolizing enzymes elevated in multiple mouse models of slow aging." Ph.D. thesis defense, CMB, University of Michigan

Posters

02/25/2014

Michael J. Steinbaugh*, Sri Devi Narasimhan*, Stacey Robida-Stubbs*, Prashant Raghavan, Lorenza Moronetti, Theresa Operana, and T. Keith Blackwell. "Germline stem cells regulate aging through the SKN-1/Nrf transcription factor." Harvard Genetics Retreat, Broad Institute

04/02/2012

Michael J. Steinbaugh, Liou Y. Sun, Andrzej Bartke, and Richard A. Miller. "Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan." 7th Annual Geriatrics Center Biogerontology Symposium, University of Michigan

11/03/2011

Michael J. Steinbaugh, Liou Y. Sun, and Richard A. Miller. "Xenobiotic metabolism genes are upregulated in long-lived mice." 10th Annual Pathology Research Symposium, University of Michigan

09/09/2011

Michael J. Steinbaugh, Liou Y. Sun, and Richard A. Miller. "Xenobiotic metabolism genes are upregulated in long-lived mice." 31st Annual CMB Symposium, University of Michigan

04/27/2011

Michael J. Steinbaugh, Liou Y. Sun, and Richard A. Miller. "Xenobiotic metabolism genes are upregulated in long-lived mice." 6th Annual Geriatrics Center Biogerontology Symposium, University of Michigan

09/10/2010

Michael J. Steinbaugh, Liou Y. Sun, Alex F. Bokov, Arlan Richardson, and Richard A. Miller. "Stress kinases: altered in fibroblasts and liver of dwarf mice." 30th Annual CMB Symposium, University of Michigan

07/25/2010

Michael J. Steinbaugh, Liou Y. Sun, Alex F. Bokov, Arlan Richardson, and Richard A. Miller. "Stress kinases: altered in fibroblasts and liver of dwarf mice." 10th International Symposium on Neurobiology and Neuroendocrinology of Aging, Bregenz, Austria. Exp Gerontol 46:210. doi:10.1016/j.exger.2010.11.019

04/20/2010

Michael J. Steinbaugh, Liou Y. Sun, and Richard A. Miller. "Suppression of ERK1/2 activation in response to oxidative stress in stress resistant, long-lived dwarf mice." 5th Annual Geriatrics Center Biogerontology Symposium, University of Michigan

02/01/2010

Liou Y. Sun, Michael J. Steinbaugh, Michal M. Masternak, Andrzej Bartke, and Richard A. Miller. "Fibroblasts from long-lived Snell and GHRKO mutant mice show diminished ERK phosphorylation but exaggerated induction of immediate early genes." Keystone Symposia on Molecular and Cellular Biology: New insights into healthspan and diseases of aging: From molecular to functional senescence, Tahoe City, CA, USA

09/11/2009

Michael J. Steinbaugh, Liou Y. Sun, and Richard A. Miller. "Mechanisms of enhanced stress resistance in long-lived dwarf mice." 29th Annual CMB Symposium, University of Michigan

09/05/2008

Michael J. Steinbaugh, Ayesha Rahman, and Richard A. Miller. "The role of IGF-1 signaling in the cellular stress resistance of long-lived dwarf mice." 28th Annual CMB Symposium, University of Michigan

Research Support

06/14-06/15

Training grant in diabetes and metabolism
NIH/NIDDK; 5T32DK007260 (PI: Blackwell TK)

09/13-06/14

Regulation of SKN-1/Nrf by germline stem cells
NIH/NIA; 1R21AG043949 (PI: Blackwell TK)

12/12-05/13

Myra Reinhard Family Foundation Award (PI: Blackwell TK)

09/12-08/13

Regulation of SKN-1 functions by insulin-like signaling in C. elegans
NIH/NIGMS; 5R01GM062891 (PI: Blackwell TK)

04/11-08/12

Lifespan and mechanisms of stress resistance in GH/IGF mutants
NIH/NIA; 5P01AG031736 (PIs: Bartke A; Miller RA)

04/08-04/11

Biomedical research training in the biology of aging
NIH/NIA; 5T32AG000114 (PIs: Miller RA; Pletcher SD)

04/06-04/07

Cellular and Molecular Biology at Michigan
NIH/NIGMS; 5T32GM007315 (PI: Schwartz J)

09/05-03/06

Program in Biomedical Sciences, University of Michigan Medical School

Honors and Awards

2010

University of Michigan Rackham Conference Travel Grant to attend the 10th International Symposium on Neurobiology and Neuroendocrinology of Aging in Bregenz, Austria

2008

Ellison Medical Foundation Award to attend the Marine Biological Laboratory Molecular Biology of Aging course

2005

UCLA MIMG Departmental Honors

2005

UCLA College of Letters and Science Honors

2004-05

UCLA College of Letters and Science Dean’s Honors List

Teaching Experience

Mentoring

09/13-Pres.

Rohan Goel, Undergraduate Student, Harvard University '15

09/11-04/12

Varol Ulas Ozkurede, Ph.D. Student, University of Michigan Medical School

Courses

01/09/14

Genetics 390, Genetics Boot Camp laboratory module, Harvard Medical School

09/08-12/08

Teaching Assistant, DENT 525 001 "Cellular structure/function and pathogen biology", University of Michigan School of Dentistry

01/04-02/04

CityLab student mentor, UCLA

09/03-12/03

Undergraduate assistant, LS 194 "Teaching practicum in life science", UCLA

Professional Societies

Skills

Genetics

Experienced with qRT-PCR, RNAi, and vector cloning. Currently learning RNA-seq and CRISPR-based gene editing. Have performed research with C. elegans and mouse models.

Molecular Biology

Skilled at performing protein immunoblots, cell fractionation/organelle enrichment, and live cell imaging of GFP-labeled proteins. Also familiar with flow cytometry, including live animal sorting of C. elegans with COPAS Biosort.

Web design

Operated my own web design company during high school and college. Notable work included the launch version of GigaOm with Om Malik, now one of the most influential tech news sites on the Internet, and designs for writer and NYT/WSJ contributor Andy Kessler, consultant Louis Patler of The B.I.T. Group, consultant Robert Spears, comedian/actor Brody Stevens, and the food company Fresh Food Concepts.

Programming

Familiar with HTML5, CSS3, PHP, MySQL, Apache, ASP, R, and the UNIX command line. Also experienced with numerous software applications, including Microsoft Office, Adobe Creative Cloud, GraphPad Prism, NIH ImageJ, ABI PRISM, and Zeiss ZEN.

Prepared on 12 Apr 2014.
PDF version and references available upon request.