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Michael J. Steinbaugh, PhD
Research Fellow, Joslin Diabetes Center
1 Joslin Place, Boston, MA 02215
mike@steinbaugh.com

Curriculum Vitae available on Dropbox.

PhD level research scientist with 10 years of experience studying the biology of aging, transcription, and metabolism. Trained in genetics, molecular biology, computational biology, and microbiology. Adept at programming and bioinformatics, including analysis of next generation sequencing data. Able to work effectively in a collaborative environment.

Education

9/15-4/12

PhD, Cellular and Molecular Biology, University of Michigan

9/01-6/05

BS, Microbiology, Immunology and Molecular Genetics; Spanish Minor, UCLA

9/09-12/09

Non-Degree, Financing Technological Entrepreneurship - Venture Acceleration, Stephen M. Ross School of Business, University of Michigan

9/08

Non-Degree, Molecular Biology of Aging course, Marine Biological Laboratory

Research Experience

9/12–pres.

Research Fellow, Islet Cell and Regenerative Biology, Joslin Diabetes Center; Dept. of Genetics and Harvard Stem Cell Institute, Harvard Medical School
Mentor: T. Keith Blackwell, MD, PhD, Professor
Lipid-mediated regulation of the SKN-1/Nrf transcription factor

5/12–8/12

Research Fellow, Dept. of Pathology, University of Michigan Medical School
Mentor: Richard A. Miller, MD, PhD, Professor

9/05-4/12

PhD Student, Cellular and Molecular Biology Program, Program in Biomedical Sciences; University of Michigan Medical School and Rackham Graduate School
Mentor: Richard A. Miller, MD, PhD, Professor
Stress resistance and xenobiotic metabolism in slow-aging mice

7/04–9/04

Research Intern, The Buck Institute for Research on Aging
Mentor: Lisa M. Ellerby, PhD, Associate Professor
Modeling polyglutamine repeat disorders (Spinal-bulbar muscular atrophy, Huntington’s disease) using transgenic mouse models

9/03–6/05

Research Assistant, Dept. of Microbiology, Immunology and Molecular Genetics, UCLA
Mentor: Kenneth A. Bradley, PhD, Professor (now at Roche)
Mammalian anthrax toxin receptor and B. anthracis virulence factors

Research Interests

Publications

8/5/15

Blackwell TK, Steinbaugh MJ, Hourihan JM, Ewald CY, Isik M. SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans. Free Radic Biol Med 88:290-301. Review. [PDF] [PMC]

7/21/15

Steinbaugh MJ, Narasimhan SD, Robida-Stubbs S, Moronetti Mazzeo LE, Dreyfuss JM, Hourihan JM, Raghavan P, Operaña TN, Esmaillie R, Blackwell TK. Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence. eLife 4:e07836. [PDF] [PMC]

2/20/14

Yoon JC, Ling AJ, Isik M, Lee DY, Steinbaugh MJ, Sack LM, Boduch AN, Blackwell TK, Sinclair DA, Elledge SJ. GLTSCR2/PICT1 links mitochondrial stress and Myc signaling. Proc Natl Acad Sci U S A 111:3781-6. [PDF] [PMC]

6/12/12

Steinbaugh MJ, Sun LY, Bartke A, Miller RA. Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan. Am J Physiol Endocrinol Metab 303:E488-95. [PDF] [PMC]

9/26/09

Sun LY, Steinbaugh MJ, Masternak MM, Bartke A, Miller RA. Fibroblasts from long-lived Snell and GHRKO mutant mice show diminished ERK phosphorylation but exaggerated induction of immediate early genes. Free Radic Biol Med 47:1753-61. [PDF] [PMC]

Datasets and Repositories

1/6/16

Steinbaugh MJ. worminfo: C. elegans metadata assembled from WormBase, Ensembl, and PANTHER in R. Publicly available at GitHub.

7/21/15

Steinbaugh MJ, Dreyfuss JM, and Blackwell TK. RNA-seq analysis of germline stem cell removal and loss of SKN-1 in C. elegans. Publicly available at NCBI GEO/SRA.

Skills

Dry Lab – Bioinformatics and Programming

Wet Lab – Genetics and Molecular Biology

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