Michael J. Steinbaugh, PhD
Research Fellow, Joslin Diabetes Center
1 Joslin Place, Boston, MA 02215

Curriculum Vitae available in PDF format

PhD level research scientist with 10 years of experience studying the biology of aging, transcription, and metabolism. Trained in genetics, molecular biology, computational biology, and microbiology. Adept at programming and bioinformatics, including analysis of next generation sequencing data. Able to work effectively in a collaborative environment.

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PhD, Cellular and Molecular Biology, University of Michigan


BS, Microbiology, Immunology and Molecular Genetics; Spanish Minor, UCLA

Research Experience


Research Fellow, Islet Cell and Regenerative Biology, Joslin Diabetes Center; Dept. of Genetics and Harvard Stem Cell Institute, Harvard Medical School
Mentor: T. Keith Blackwell, MD, PhD, Professor
Research Topic: Lipid-mediated regulation of the SKN-1/Nrf transcription factor


Research Fellow, Dept. of Pathology, University of Michigan Medical School
Mentor: Richard A. Miller, MD, PhD, Professor


PhD Student, Cellular and Molecular Biology Program, Program in Biomedical Sciences; University of Michigan Medical School and Rackham Graduate School
Mentor: Richard A. Miller, MD, PhD, Professor
Research Topic: Stress resistance and xenobiotic metabolism in slow-aging mice


Research Intern, The Buck Institute for Research on Aging
Mentor: Lisa M. Ellerby, PhD, Associate Professor
Research Topic: Modeling polyglutamine repeat disorders (Spinal-bulbar muscular atrophy, Huntington’s disease) using transgenic mouse models


Research Assistant, Dept. of Microbiology, Immunology and Molecular Genetics, UCLA
Mentor: Kenneth A. Bradley, PhD, Professor (now at Roche)
Research Topic: Mammalian anthrax toxin receptor and B. anthracis virulence factors

Research Interests



Blackwell TK, Steinbaugh MJ, Hourihan JM, Ewald CY, Isik M. “SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans.Free Radic Biol Med 88:290-301. Review. [PDF]


Steinbaugh MJ, Narasimhan SD, Robida-Stubbs S, Moronetti Mazzeo LE, Dreyfuss JM, Hourihan JM, Raghavan P, Operaña TN, Esmaillie R, Blackwell TK. “Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence.eLife 4:e07836. [PDF] [PMC]

Lemieux GA and Ashrafi K. “Stressing about misplaced fat is a key to longevity.eLife 4:e10161. Editorial feature. [PDF] [PMC]


Yoon JC, Ling AJ, Isik M, Lee DY, Steinbaugh MJ, Sack LM, Boduch AN, Blackwell TK, Sinclair DA, Elledge SJ. “GLTSCR2/PICT1 links mitochondrial stress and Myc signaling.Proc Natl Acad Sci U S A 111:3781-6. [PDF] [PMC]


Steinbaugh MJ, Sun LY, Bartke A, Miller RA. “Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan.Am J Physiol Endocrinol Metab 303:E488-95. [PDF] [PMC]


Sun LY, Steinbaugh MJ, Masternak MM, Bartke A, Miller RA. “Fibroblasts from long-lived Snell and GHRKO mutant mice show diminished ERK phosphorylation but exaggerated induction of immediate early genes.Free Radic Biol Med 47:1753-61. [PDF] [PMC]

Datasets & Repositories


Steinbaugh MJ. “metadata-elegans: C. elegans metadata assembled from WormBase, Ensembl, and PANTHER in R.” Publicly available at GitHub.


Steinbaugh MJ, Dreyfuss JM, and Blackwell TK. “RNA-seq analysis of germline stem cell removal and loss of SKN-1 in C. elegans.” Publicly available at the NCBI Gene Expression Omnibus.


Dry Lab – Bioinformatics & Programming

Wet Lab – Genetics & Molecular Biology