Michael J. Steinbaugh, PhD
Research Fellow, Joslin Diabetes Center
1 Joslin Place, Boston, MA 02215
PhD level research scientist with 10 years of experience studying bioinformatics, transcription, the biology of aging, and lipid metabolism. Trained in genetics, molecular biology, and microbiology. Adept at programming, including analysis of next-generation sequencing data.
Curriculum Vitae available in PDF format.
PhD, Cellular and Molecular Biology, University of Michigan
BS, Microbiology, Immunology and Molecular Genetics; Spanish Minor, UCLA
Research Fellow, Joslin Diabetes Center and Harvard Medical School;
Islet Cell and Regenerative Biology, Dept. of Genetics, Harvard Stem Cell Institute
Project: Lipid-mediated regulation of the SKN-1/Nrf transcription factor
Mentor: Keith Blackwell
PhD Student, University of Michigan Medical School;
Cellular and Molecular Biology, Program in Biomedical Sciences, Rackham Graduate School
Project: Stress resistance and xenobiotic metabolism in slow-aging mice
Mentor: Richard Miller
Research Intern, The Buck Institute for Research on Aging
Project: Modeling polyglutamine repeat disorders (Spinal-bulbar muscular atrophy, Huntington’s disease) in mice
Mentor: Lisa Ellerby
Research Assistant, UCLA;
Dept. of Microbiology, Immunology and Molecular Genetics
Project: Mammalian anthrax toxin receptor and B. anthracis virulence factors
Mentor: Ken Bradley (now at Roche)
Blackwell TK, Steinbaugh MJ, Hourihan JM, Ewald CY, Isik M. SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans. Free Radic Biol Med 88:290-301. Review. [PDF] [PMC]
Steinbaugh MJ, Narasimhan SD, Robida-Stubbs S, Moronetti Mazzeo LE, Dreyfuss JM, Hourihan JM, Raghavan P, Operaña TN, Esmaillie R, Blackwell TK. Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence. eLife 4:e07836. [PDF] [PMC]
Yoon JC, Ling AJ, Isik M, Lee DY, Steinbaugh MJ, Sack LM, Boduch AN, Blackwell TK, Sinclair DA, Elledge SJ. GLTSCR2/PICT1 links mitochondrial stress and Myc signaling. Proc Natl Acad Sci U S A 111:3781-6. [PDF] [PMC]
Steinbaugh MJ, Sun LY, Bartke A, Miller RA. Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan. Am J Physiol Endocrinol Metab 303:E488-95. [PDF] [PMC]
Sun LY, Steinbaugh MJ, Masternak MM, Bartke A, Miller RA. Fibroblasts from long-lived Snell and GHRKO mutant mice show diminished ERK phosphorylation but exaggerated induction of immediate early genes. Free Radic Biol Med 47:1753-61. [PDF] [PMC]
Datasets and Software
seqcloudR: Common R functions for use in next-generation sequencing data analysis.
worminfo: C. elegans metadata assembled from WormBase, Ensembl, and PANTHER.
Steinbaugh MJ, Dreyfuss JM, and Blackwell TK. RNA-seq analysis of germline stem cell removal and loss of SKN-1 in C. elegans.
Twitter, GitHub, LinkedIn, PubMed, Google Scholar, ORCID