Headshot

Michael J. Steinbaugh, PhD
Research Fellow, Joslin Diabetes Center
1 Joslin Place, Boston, MA 02215
mike@steinbaugh.com

PhD level research scientist with 10 years of experience studying the biology of aging, transcription, and metabolism. Trained in genetics, molecular biology, computational biology, and microbiology. Adept at programming and bioinformatics, including analysis of next generation sequencing data.

Curriculum Vitae available on Dropbox.

Research Interests

Education

2005-12

PhD, Cellular and Molecular Biology, University of Michigan

2001-05

BS, Microbiology, Immunology and Molecular Genetics; Spanish Minor, UCLA

Research Experience

2012–pres.

Research Fellow, Islet Cell and Regenerative Biology, Joslin Diabetes Center; Dept. of Genetics and Harvard Stem Cell Institute, Harvard Medical School
Project: Lipid-mediated regulation of the SKN-1/Nrf transcription factor
Mentor: T. Keith Blackwell, MD, PhD, Professor

2005-12

PhD Student, Cellular and Molecular Biology Program, Program in Biomedical Sciences; University of Michigan Medical School and Rackham Graduate School
Project: Stress resistance and xenobiotic metabolism in slow-aging mice
Mentor: Richard A. Miller, MD, PhD, Professor

2004

Research Intern, The Buck Institute for Research on Aging
Project: Modeling polyglutamine repeat disorders (Spinal-bulbar muscular atrophy, Huntington’s disease) in mice
Mentor: Lisa M. Ellerby, PhD, Associate Professor

2003-05

Research Assistant, Dept. of Microbiology, Immunology and Molecular Genetics, UCLA
Project: Mammalian anthrax toxin receptor and B. anthracis virulence factors
Mentor: Kenneth A. Bradley, PhD, Professor (now at Roche)

Publications

8/5/15

Blackwell TK, Steinbaugh MJ, Hourihan JM, Ewald CY, Isik M. SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans. Free Radic Biol Med 88:290-301. Review. [PDF] [PMC]

7/21/15

Steinbaugh MJ, Narasimhan SD, Robida-Stubbs S, Moronetti Mazzeo LE, Dreyfuss JM, Hourihan JM, Raghavan P, Operaña TN, Esmaillie R, Blackwell TK. Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence. eLife 4:e07836. [PDF] [PMC]

2/20/14

Yoon JC, Ling AJ, Isik M, Lee DY, Steinbaugh MJ, Sack LM, Boduch AN, Blackwell TK, Sinclair DA, Elledge SJ. GLTSCR2/PICT1 links mitochondrial stress and Myc signaling. Proc Natl Acad Sci U S A 111:3781-6. [PDF] [PMC]

6/12/12

Steinbaugh MJ, Sun LY, Bartke A, Miller RA. Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan. Am J Physiol Endocrinol Metab 303:E488-95. [PDF] [PMC]

9/26/09

Sun LY, Steinbaugh MJ, Masternak MM, Bartke A, Miller RA. Fibroblasts from long-lived Snell and GHRKO mutant mice show diminished ERK phosphorylation but exaggerated induction of immediate early genes. Free Radic Biol Med 47:1753-61. [PDF] [PMC]

Datasets and Repositories

4/26/16

Steinbaugh MJ. seqcloudR: Common R functions for use in next-generation sequencing data analysis. R package, hosted at GitHub (active).

12/17/15

Steinbaugh MJ. worminfo: C. elegans metadata assembled from WormBase, Ensembl, and PANTHER. R package, hosted at GitHub (active).

7/21/15

Steinbaugh MJ, Dreyfuss JM, and Blackwell TK. RNA-seq analysis of germline stem cell removal and loss of SKN-1 in C. elegans. NCBI GEO/SRA dataset.

Technical Expertise

Dry Lab – Bioinformatics and Programming

Wet Lab – Genetics and Molecular Biology

Twitter | LinkedIn | GitHub | PubMed | Scholar