Michael J. Steinbaugh, PhD

Research Fellow, Joslin Diabetes Center
1 Joslin Place, Boston, MA 02215
mike@steinbaugh.com | (617) 299-1384


PhD level research scientist with 10 years of experience studying bioinformatics, transcription, the biology of aging, and lipid metabolism. Trained in genetics, molecular biology, and microbiology. Adept at programming, including analysis of next-generation sequencing data.

Curriculum Vitae available in DOCX or PDF formats.


Education

2012

PhD, Cellular and Molecular Biology, University of Michigan

2005

BS, Microbiology, Immunology and Molecular Genetics; Spanish Minor, UCLA

Research Experience

2012–pres.

Research Fellow, Joslin Diabetes Center and Harvard Medical School
Lipid-mediated regulation of the SKN-1/Nrf transcription factor
Mentor: T. Keith Blackwell

2005-12

PhD Student, University of Michigan Medical School
Stress resistance and xenobiotic metabolism in slow-aging mice
Mentor: Richard A. Miller

2003-05

Research Assistant, UCLA
Phage display library screening for Bacillus anthracis Protective Antigen-competitive peptides
Mentor: Kenneth A. Bradley

2004

Research Intern, The Buck Institute for Research on Aging
PCR optimization of polyglutamine repeats in mouse models of Huntington’s Disease and SBMA
Mentor: Lisa M. Ellerby

Research Interests

Publications

Blackwell TK, Steinbaugh MJ, Hourihan JM, Ewald CY, Isik M. (2015). SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans. Free Radic Biol Med 88:290-301. Review. [PDF]

Steinbaugh MJ, Narasimhan SD, Robida-Stubbs S, Moronetti Mazzeo LE, Dreyfuss JM, Hourihan JM, Raghavan P, Operaña TN, Esmaillie R, Blackwell TK. (2015). Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence. eLife 4:e07836. [PDF]

Yoon JC, Ling AJ, Isik M, Lee DY, Steinbaugh MJ, Sack LM, Boduch AN, Blackwell TK, Sinclair DA, Elledge SJ. (2014). GLTSCR2/PICT1 links mitochondrial stress and Myc signaling. Proc Natl Acad Sci U S A 111:3781-6. [PDF]

Steinbaugh MJ, Sun LY, Bartke A, Miller RA. (2012). Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan. Am J Physiol Endocrinol Metab 303:E488-95. [PDF]

Sun LY, Steinbaugh MJ, Masternak MM, Bartke A, Miller RA. (2009). Fibroblasts from long-lived Snell and GHRKO mutant mice show diminished ERK phosphorylation but exaggerated induction of immediate early genes. Free Radic Biol Med 47:1753-61. [PDF]

Datasets and Software

R Packages

seqcloudr: Next-generation sequencing data analysis utilities.

worminfo: C. elegans genome and RNAi library annotations. Metadata dynamically assembled from WormBase, Ensembl, and PANTHER. Support for ORFeome and Ahringer feeding RNAi libraries.

Other Code Development

seqcloudbash: Bash shell scripts for high performance computing clusters.

RNA-Seq Datasets

Steinbaugh MJ, Dreyfuss JM, and Blackwell TK. (2015). RNA-seq analysis of germline stem cell removal and loss of SKN-1 in C. elegans.